Research on selection of susceptibility genes for the urinary sodium to potassium ratio to blood pressure and utilization for health guidance

2023 Fiscal Year Final Research Report

• Project/Area Number: 20K10466
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 58030:Hygiene and public health-related: excluding laboratory approach
• Research Institution: Tohoku University
• Principal Investigator: Kogure Mana 東北大学, 東北メディカル・メガバンク機構, 講師 (30789764)
• Co-Investigator(Kenkyū-buntansha): 寳澤 篤 東北大学, 東北メディカル・メガバンク機構, 教授 (00432302)
• Project Period (FY): 2020-04-01 – 2024-03-31
• Keywords: 高血圧 / ナトリウム・カリウム比 / ナトリウム・カリウム比感受性 / ゲノム / 保健指導

Outline of Final Research Achievements

This study aimed to identify susceptibility genes for the urinary sodium to potassium ratio (Na/K ratio) using data from the Tohoku Medical Megabank community-based cohort study.
We performed GWAS on the estimated 24-h urinary sodium, potassium and Na/K ratio respectively, and found several loci were statistically significant. Furthermore, in relation to systolic blood pressure, we examined the interaction of genotype with estimated 24-h urinary sodium, potassium and Na/K ratio. The results showed no significant interaction of genotype with estimated 24-h urinary sodium, potassium and Na/K ratio.
We will conduct further examination through collaborative research to identify susceptibility genes for the urinary Na/K ratio.

Free Research Field

栄養疫学、疫学、公衆衛生

Academic Significance and Societal Importance of the Research Achievements

近年、ゲノム測定の進歩により、廉価で個人の遺伝子多型の測定が可能な時代となった。もしNa/K比の感受性があった場合、「減塩および野菜摂取増加」を中心とした食事指導の強化が可能となり、Na/K比の感受性がなかった場合は、「減塩や野菜摂取増加」以外の生活習慣指導の提案等が可能となる。このようにNa/K比の感受性遺伝子が同定できれば、Na/K比感受性に基づいた血圧低下方法の提案が可能となり、今後の高血圧予防、ひいては循環器疾患対策を実施する上で非常に重要な知見となる。