2022 Fiscal Year Final Research Report
In search for nutritional biomarkers of 24-hour urine to prevent dementia
| Project/Area Number |
20K10517
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 58030:Hygiene and public health-related: excluding laboratory approach
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| Research Institution | Mukogawa Women's University |
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Principal Investigator |
YAMORI Yukio 武庫川女子大学, 国際健康開発研究所, 教授 (80025600)
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| Co-Investigator(Kenkyū-buntansha) |
森 真理 東海大学, 健康学部, 特任准教授 (70399343)
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | 長浜コホート研究 / 脊振研究 / 24時間尿中栄養バイオマーカー / 葉酸 / ホモシステイン / 認知機能 / 脳画像解析 / 予知・予防医学（先制医療） |
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| Outline of Final Research Achievements |
We could demonstrate the inverse association of soy isoflavones (Is) and fish taurine(T) in 24- hour urine samples with coronary heart diseases by WHO CARDIAC study to conclude, optimum salted soy and fish intakes were indispensable to extending healthy life expectancy. Is and T intakes in Japanese were epidemiologically associated with serum folate(F) elevation, and the epidemiological data of the reduction of dementia after the legal fortification of wheat powder by F in USA and the effective reduction of the brain atrophy in the elderly by the supplement intervention of F in England supported the potential effects of serum F elevation on dementia prevention.
We investigated the mechanisms of F elevation for reducing the risk of cognitive impairment, in Nagahama Cohort and particularly focused on the investigation of homocysteine association of the blood and urine in Seburi Study for detecting dementia risk by urinalysis for the prevention.
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| Free Research Field |
予防栄養学
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| Academic Significance and Societal Importance of the Research Achievements |
脳卒中モデルの開発に始まる大豆・魚の栄養の脳卒中の実験的予防栄養がヒトの疫学研究でもHDLを増加させ、動脈硬化の予防が可能で米国では葉酸(F)の法的添加後に認知症が低減し、英国ではFやビタミンB6、B12のサプリメントで高齢者の脳萎縮が抑えられたことから、Fを増加させる和食が勧められる。Fはホモシステイン(HC)を減少させるが、高齢者の健診で血中Hと尿中Hの相関を証明し、24時間採尿で尿中HをモニターしてFを増加させる適塩で大豆・魚を摂り、野菜からのカリウム摂取を勧めれば、食生活によって認知機能の低減を予防し得ると期待される。本研究は尿のモニターによる認知症の先制医療の進展に貢献しうる。
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