2023 Fiscal Year Final Research Report
Can salivary biomarkers be a new predictor of postoperative delirium?
| Project/Area Number |
20K10782
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Review Section |
Basic Section 58060:Clinical nursing-related
|
|---|
| Research Institution | Shinshu University |
|---|
Principal Investigator |
FUKE Megumi (志村愛) 信州大学, 学術研究院医学系(医学部附属病院), 助教 (10447740)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
和田 有子 信州大学, 学術研究院医学系, 講師 (30419410)
瀬戸 達一郎 信州大学, 学術研究院医学系, 教授 (70362118)
中村 敏範 信州大学, 学術研究院医学系(医学部附属病院), 助教 (80755091)
篠山 大明 信州大学, 学術研究院医学系, 准教授 (90447764)
|
|---|
| Project Period (FY) |
2020-04-01 – 2024-03-31
|
| Keywords | 術後せん妄 / 唾液アミラーゼ / 心臓血管手術 |
|---|
| Outline of Final Research Achievements |
Postoperative delirium is common in cardiovascular surgery. In addition, cardiovascular disease is often complicated by depression and anxiety symptoms, and it is presumed that anxiety and stress are more likely to occur. In order to investigate the relationship between postoperative delirium and preoperative stress, salivary amylase was measured preoperatively and anxiety was assessed using GAD7.
17 of the 43 patients who consented to the study had postoperative delirium. 19 of the 43 patients who tested with GAD7 had preoperative anxiety. 20 of the 40 patients whom amylase measurement was available were judged to be stressed by preoperative salivary amylase.Statistical analyses were performed on these and other factors, but no significant association was found.
|
| Free Research Field |
心臓血管外科分野
|
| Academic Significance and Societal Importance of the Research Achievements |
術後せん妄は患者の生命予後を悪化する。心臓血管手術では術後せん妄の頻度が高く、高齢社会で患者が増え、医療費増大という社会問題にも影響する術後せん妄は予防、対策が急務である。本研究では心臓血管疾患とストレスの関係という精神的要因に着目し、唾液バイオマーカーで術前のストレス評価を行い、術後せん妄との関連を解明できれば、これまでの身体的要因を中心とした研究と異なり、新たな発見が得られるはずだった。今回調べた因子で新たな発見はなかったが、術前患者の多くが抱える不安やストレスを数値化できた。患者がストレス・不安を表出するとも限らず、可視化することで様々な対応がとれる可能性が考えられた。
|
