2024 Fiscal Year Final Research Report

Investigation of the mechanism of sleep reduction: a twin study of genetic-environment interaction.

Research Project

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Project/Area Number	20K11091
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Review Section	Basic Section 58080:Gerontological nursing and community health nursing-related
Research Institution	Tenri University (2023-2024) Tenri Health Care University (2022) Kio University (2020-2021)
Principal Investigator	Inui Fujio 天理大学, 医療学部, 教授 (80469551)
Co-Investigator(Kenkyū-buntansha)	松本大輔畿央大学, 健康科学部, 准教授 (20511554) 渡邉幹夫大阪大学, 大学院医学系研究科, 教授 (50294088) 本多智佳滋賀医科大学, 医学部, 客員准教授 (40625498) 冨澤理恵大阪大学, 大学院医学系研究科, 招へい教員 (20584551)
Project Period (FY)	2020-04-01 – 2025-03-31
Keywords	行動遺伝学 / 双生児研究法 / 睡眠時間
Outline of Final Research Achievements	We analysed factors thought to be related to sleep, the subject of this study (the relationship between alcohol consumption, smoking, and depressive symptoms and sleep time), into genetics and environment. However, we were unable to obtain results that could clearly explain the mechanism behind the reduction in sleep time in Japan. In addition, no genetic correlation was confirmed with factors that reduce sleep time (alcohol consumption, smoking, diabetes, and depressive symptoms). Since this data is from 2020, during the COVID-19 pandemic, it is highly likely that it does not accurately reflect the relationship between social and environmental factors specific to Japan and reduced sleep time, which was initially a focus due to the pandemic.
Free Research Field	行動遺伝学
Academic Significance and Societal Importance of the Research Achievements	睡眠時間と関連が指摘されている，飲酒，喫煙，うつ症状，身体活動などのライフスタイルと睡眠時間の関連を遺伝要因と環境要因に分解して解析したが，十分な証拠が得られなかった。このことだけで関連がないとは言えず，単独での関連は限定的だが，より複雑に総合的に関連していると考えられるため，より大規模な研究の必要性を示唆している。また，本研究を通して明らかとなった，細胞の状態を表す指標と筋肉量とは別のものであることなどから，単純に運動することだけが良いのではなく，身体的の質の評価が睡眠など精神的な質とも関連している可能性がある。