Management of the malignant cycle between heart failure and arrhythmias

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K11152
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 59010:Rehabilitation science-related
• Research Institution: Yamagata University
• Principal Investigator: Arimoto Takanori 山形大学, 医学部, 助教 (80400547)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 心房細動 / 心不全 / 心臓リハビリテーション

Outline of Final Research Achievements

The COVID19 pandemic occurred along with the heart failure (HF) pandemic, the cardiovascular diseases mortality was higher than predicted value. The research focused on the relationship of reactive oxygen species to the vicious cycle of HF and atrial fibrillation (AF). Xanthine oxidoreductase (XOR) plays an important role in generating reactive oxygen species. HF-AF patients had significantly higher plasma XOR activity. Plasma XOR activity proved to be a reliable indicator for major adverse cardiovascular events. For the management of the vicious cycle, I have reported the usefulness of drugs, catheter ablation, and cardiac rehabilitation (CR). Especially, CR directed by an arrhythmia specialist has attracted much attention and received symposium presentations and awards at academic conferences. In addition, using the Japanese Heart Rhythm Society Registry, we were able to report the relationship between physical activity and prognosis in patients with pacemaker implantation.

Free Research Field

循環器内科

Academic Significance and Societal Importance of the Research Achievements

不整脈診療・心不全診療はそれぞれに独自の発展を遂げ、近年、それぞれの治療方法の進展には目を見張るものがある。薬物治療やカテーテル治療、デバイス治療は当然のことながら、相互的な治療として「心臓リハビリテーション」について新たに報告できたことが非常に新しく独自性のある視点であった。実際、日本不整脈心電学会や日本心臓リハビリテーション学会でシンポジウムを務めたり、優秀賞を受賞したりすることができた。２０２３年には日本循環器学会の最も大きい会場で教育講演を務めることもでき、多くの循環器内科医に啓蒙することができた。これらの治療中、稀で臨床応用可能な症例を経験し、計６例の症例報告も書くことができた。