Pysical activity and remission on the patients with Rheumatoid Arthritis

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K11169
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 59010:Rehabilitation science-related
• Research Institution: Showa University
• Principal Investigator: Toyoshima Yoichi 昭和大学, 医学部, 講師 (10439440)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 関節リウマチ / 身体活動量 / 加速度計 / 疾患活動性

Outline of Final Research Achievements

This study evaluated the relationship between rheumatoid arthritis (RA) disease activity level and physical activity (PA) by using an accelerometer and self-reported questionnaire.
The cross-sectional study was part of a cohort study designed to determine disease activity is associated with PA in RA patients. We classifed patients with a DAS28-ESR of less than and higher than 3.2 into the low-disease-activity (LDA) group and moderate/high-disease-activity (MHDA) group, respectively. We measured PA using a triaxial accelerometer. 34 patients were included in the study.
There was no signifcant association between RA disease activity level and accelerometer-measured PA with adjustment for age and Functional Assessment of Chronic Illness Therapy-Fatigue score. There was no correlation between accelerometer-measured MVPA and self-reported MVPA in the MHDA group, but these factors were correlated in the LDA group.

Free Research Field

医学

Academic Significance and Societal Importance of the Research Achievements

これまで身体活動量（PA）は、簡便なため質問形式にて評価が行われてきた。しかし、関節リウマチ（RA）患者では、その疾患活動性のため低PAの患者さんが多く、質問形式による評価の正確性は定かではなかった。
そのため、この研究ではRAの活動性別にPAを質問形式と正確にPAが測定できる加速度計を用いて評価した。
この研究の結果により、関節リウマチの活動性が落ち着いている群では、質問形式は加速度計から得られたPAと同等であった。しかし、関節リウマチの活動性が高い患者群では、質問形式から得られたPAは過大評価される傾向にあることが分かった。