The effects of exercise on the dynamics of blood lactate and myokines

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K11175
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 59010:Rehabilitation science-related
• Research Institution: Kawasaki Medical School
• Principal Investigator: Himi Naoyuki 川崎医科大学, 医学部, 准教授 (70412161)
• Co-Investigator(Kenkyū-buntansha): 宮本 修 川崎医科大学, 医学部, 教授 (00253287) ; 丸山 恵美 川崎医科大学, 医学部, 助教 (30792072)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: マイオカイン / 運動療法

Outline of Final Research Achievements

The secretion dynamics of muscle-derived nutritional factors (myokines) according to the type of exercise were analyzed. Rats were divided into non-exercise and exercise groups (endurance forced running, spontaneous running, transcutaneous electrical stimulation and rotarod dexterity running), and myokines (BDNF, IGF-1, irisin and cathepsin B) were measured. There was no significant difference in post-exercise myokine levels in healthy rats. In the cerebral infarction rats by microsphere embolism, although no significant difference was observed when comparing between muscles, cathepsin B and IGF-1 showed higher concentrations in the soleus muscle than in the gastrocnemius muscle in all exercise groups. We hypothesized that the kinetics of myokines secretion might be different due to differences in muscle metabolism. In addition, a recovery tendency was confirmed in all exercise groups against memory dysfunction caused by cerebral infarction.

Free Research Field

神経生理学

Academic Significance and Societal Importance of the Research Achievements

現在の運動療法の選定には、科学的な根拠よりもむしろ経験に基づいた運動レシピを用いていることが多い。ここに科学的な根拠を与えるために、本研究では各種運動療法を行うことにより筋から分泌される因子であるマイオカインに着目し、その分泌濃度を解析し、効果的な運動療法を考察、提案することを目的とする。特に脳神経系疾患の発症後の急性期における運動療法については、その有益性とリスクのバランスを考えながら行う必要があるが、それについても、マイオカイン分泌の観点からエビデンスを与えうるものと期待できる。