Methods of controlling magnetism to activate the growth of nervous system cells and systems for reconstructing brain and motor functions

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K11209
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 59010:Rehabilitation science-related
• Research Institution: Oita University
• Principal Investigator: Fujiki Minoru 大分大学, 医学部, 教授 (90231563)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 皮質脊髄路 / 運動機能回復 / 磁気刺激 / 可塑性 / 電気刺激 / マッピング / 神経再生 / 運動誘発殿位

Outline of Final Research Achievements

The primary investigator's "Patented Technology for Corticospinal Tract Regeneration" was verified to be effective and safe. The study also comprehensively verified the optimal conditions for recovery of motor function by combining the previously published basic research and rehabilitation methods developed in clinical practice, and summarized the potential of this technology in the future. Study collaborator Steward reported that PTEN deletion is a key factor in corticospinal tract regeneration after spinal cord injury (J. Neurosci. 2014, Nat. Neurosci. 2010), and the primary investigator's two patents (JP-A2012-187149;①) and (JP-7189594;②) a new patent (JP-7201986;③) that was generated by practical applications (JP-7201986;③). (3) Method of controlling magnetism to activate the proliferation of nervous system cells and system for reconstructing brain and motor functions), a prototype experimentally demonstrated the same effect.

Free Research Field

神経機能再建

Academic Significance and Societal Importance of the Research Achievements

新たな特許第7201986;③による診断機器としての有用性(倫理委員会審査_protocol number: 265)は健常人並びに一部の脳卒中後片麻痺・嚥下障害を有する患者さんにおいて安全に施行できることが確認された。