2023 Fiscal Year Final Research Report

Simplified exercise rehabilitation in heart failure with preserved left ventricular ejection fraction

Research Project

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Project/Area Number	20K11255
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Review Section	Basic Section 59010:Rehabilitation science-related
Research Institution	Ehime University
Principal Investigator	Inoue Katsuji 愛媛大学, 医学系研究科, 准教授 (50512167)
Co-Investigator(Kenkyū-buntansha)	東晴彦愛媛大学, 医学部附属病院, 講師(特定教員) (10598634) 木下将城愛媛大学, 医学部附属病院, 医員 (60838564) 山口修愛媛大学, 医学系研究科, 教授 (90467580)
Project Period (FY)	2020-04-01 – 2024-03-31
Keywords	心不全 / 運動療法 / 心肺運動負荷試験 / 活動量計
Outline of Final Research Achievements	To introduce a simplified exercise rehabilitation in outpatients with heart failure. The goal of exercise rehabilitation was defined as 40-60% exercise based on cardio-pulmonary test. Among 8 patients, 7 patients achieved the goal of exercise rehabilitation guided by recording daily activity with Omron Activity Meter, however, one patient did not. In 7 patients who had the targeted daily activity, exercise capacity was improved. The cardiac etiologies in these 7 patients were dilated cardiomyopathy and valvular heart disease with cardiac functional reserve. The remaining 2 patients did not gain the improvement of exercise capacity. These patients received catheter ablation for atrial fibrillation or aggressive medical treatment for heart failure. This study suggests that the simplified exercise rehabilitation was practical, enabling to propose additional therapeutic options.
Free Research Field	リハビリテーション
Academic Significance and Societal Importance of the Research Achievements	本研究は左室駆出率が保たれた心不全（HFpEF）における簡便な運動処方を提案することを目的とした。HFpEFは左室拡張障害に加え、加齢、高血圧、糖尿病、慢性腎臓病、サルオペニアなどの病態が重積している。運動療法はHFpEF症例に対して運動耐容能改善効果をもたらす。本研究は、活動量計を用いた簡易運動療法を提案し、運動習慣を根付かせること、さらには運動耐容能を改善させることを目的とした。結果、運動療法を継続し得た症例は運動耐容能の改善に寄与したと考えられた。今回使用した活動量計は簡易運動療法は、簡便で実用的なリハビリテーションと考えられた。