Clinical study of functional recovery after stroke using with EEG investigations

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K11263
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 59010:Rehabilitation science-related
• Research Institution: International University of Health and Welfare
• Principal Investigator: Kakuda Wataru 国際医療福祉大学, 医学部, 主任教授 (00453788)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: リハビリテーション / 脳卒中 / 片麻痺 / 脳波検査 / 機能回復 / Correlation coefficient

Outline of Final Research Achievements

Post-stroke patients with hemiparesis who were admitted to our convalescent rehabilitation ward in order to receive long-term rehabilitation were studied. For all subjects of this study, EEG recording was serially performed and correlation coefficient was calculated based on the findings of EEG. Generally, correlation coefficient is considered to indicate the extent of functional neural connectivity between some cortical areas of the brain. As the results of this study, it has been shown that the increase of correlation coefficient in some areas of the lesional hemisphere is significantly related to the extent of motor functional recovery with rehabilitative training. In addition, the increase of correlation coefficient with motor task activation in the lesional hemisphere can be a predictor of favorable functional outcome in the hemiparetic upper limb.

Free Research Field

リハビリテーション医学

Academic Significance and Societal Importance of the Research Achievements

脳卒中後片麻痺の機能回復のメカニズムには、不明なところが多かった。しかしながら、本研究の成果として、通常のデジタル脳波検査でcorrelation coefficient（神経機能連絡の程度を示唆する）を経時的に測定することによって、そのメカニズムをある程度は推測できることが示された。また、運動負荷時のcorrelation coefficientを測定することで、その後における機能回復を予測できる可能性も示唆された。本研究は、脳卒中後片麻痺の病態解明に、デジタル脳波検査を応用することが可能であることを示した点で重要である。