Verification of the effectiveness of very early stroke rehabilitation and development of new treatment strategies

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K11269
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 59010:Rehabilitation science-related
• Research Institution: Niigata University of Health and Welfare
• Principal Investigator: Tamakoshi Keigo 新潟医療福祉大学, リハビリテーション学部, 講師 (30632658)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 脳卒中 / リハビリテーション / 運動療法

Outline of Final Research Achievements

This study examined the effect of very early exercise on motor recovery and associated brain damage following intracerebral hemorrhage (ICH) in rats. Collagenase solution was injected into the left striatum to induce ICH. Rats were randomly assigned to receive placebo surgery without exercise or ICH without (ICH) or with very early exercise within 24 h of surgery (ICH+VET). We observed sensorimotor behaviors before surgery, after surgery pre-exercise, and post-exercise. Post-exercise brain tissue was collected 27 h after surgery to investigate Il1b, Tgfb1, and Igf1 mRNA levels in the striatum and sensorimotor cortex. We observed significantly increased skillful sensorimotor impairment and significantly higher Il1b mRNA levels in the striatum of the ICH+VET group compared with the ICH group. Our results suggest that very early exercise may be associated with an exacerbation of motor dysfunction due to increased neuronal death and region-specific changes in inflammatory factors.

Free Research Field

基礎理学療法

Academic Significance and Societal Importance of the Research Achievements

現在の脳卒中超急性期リハビリテーションには科学的根拠が不十分な点が多くあるため早急な解明研究が必要である．特に，脳出血後の超急性期リハビリテーションの効果を分子細胞基盤から全容解明する実証的研究は世界的にも未だ試みられていないため，本研究成果は，臨床研究に向けた基盤データとして活用でき，トランスレーショナル研究の足掛かりとなりえる．さらに，我が国に留まらず世界各国において，脳卒中超急性期リハビリテーション方針の策定や再考のための研究資料となりえ，今後の治療戦略に役立つ．