Basic research aiming to improve the diagnosis and treatment of skeletal muscle injury using ultrasound technique

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K11360
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 59020:Sports sciences-related
• Research Institution: Osaka University
• Principal Investigator: Kanamoto Takashi 大阪大学, 大学院医学系研究科, 准教授 (20512049)
• Co-Investigator(Kenkyū-buntansha): 中田 研 大阪大学, 大学院医学系研究科, 教授 (00283747) ; 前 達雄 大阪大学, 大学院医学系研究科, 招へい教授 (10569734)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 骨格筋損傷 / 超音波診断装置/エコー / 動物モデル / エコーガイド下インターベンション

Outline of Final Research Achievements

There is insufficient evidence regarding the relationship between ultrasound imaging and tissue findings in skeletal muscle injury and the significance of ultrasound guided drug infusion. In this study, a new cardiotoxin (CTX)-induced muscle injury model and a traumatic severe muscle contusion model with muscle rupture were designed and created to investigate the usefulness of ultrasounod in the treatment of skeletal muscle injury. 24 hours after CTX injection, quantitative assessment of the muscle injury lesion by ultrasound was compared with tissue staining. A strong correlation was observed between these two assesments. When Fast Green solution was injected into the injured area under ultrasound guidance, areas of staining were observed around the muscle fibers in the injured area. The results support the possibility of quantitative evaluation of traumatic skeletal muscle injury by ultrasound and the significance of ultrasound guided solution injection.

Free Research Field

スポーツ医学、リハビリテーション

Academic Significance and Societal Importance of the Research Achievements

外傷による骨格筋損傷において、エコーによる診断や血腫吸引・薬液注入などのエコーガイド下介入が頻用される。しかし、その定量性や手技が治療成績に及ぼす影響に関する十分なエビデンスは無い。本研究の成果はエコーによる外傷性骨格筋損傷の定量評価の可能性とエコーガイド下溶液注入の意義を支持するものであり、今後の治療へのフィードバックが期待される。