2022 Fiscal Year Final Research Report
Role of iron metabolism in protein metabolism in skeletal muscle
| Project/Area Number |
20K11364
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 59020:Sports sciences-related
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| Research Institution | The University of Shiga Prefecture |
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Principal Investigator |
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | 骨格筋 / 鉄 / タンパク質 |
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| Outline of Final Research Achievements |
In this study, we examined the effects of iron metabolism on protein metabolism in skeletal muscle. Skeletal muscle cells cultured in iron-deficient medium showed a reduced response to protein synthesis stimulation. In addition, protein synthesis stimulation by muscle contraction was also attenuated in experimental animals subjected to dietary iron deficiency. These results suggest that iron nutritional status may affect protein metabolism in skeletal muscle.
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| Free Research Field |
運動生理学
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| Academic Significance and Societal Importance of the Research Achievements |
鉄欠乏が骨格筋のタンパク質代謝に与える影響を明らかにしたことに学術的な意義がある。また、本研究は、骨格筋機能の維持に、たんぱく質摂取だけでなく、微量栄養素も重要な働きを担っていることを示した点で、社会的な意義があると言える。
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