Development of a new hypoxia training method for the prevention of lifestyle-related diseases focusing on novel myokines

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K11401
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 59020:Sports sciences-related
• Research Institution: Toyo University (2021-2022); Chukyo University (2020)
• Principal Investigator: Kon Michihiro 東洋大学, ライフデザイン学部, 教授 (00455445)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 低酸素 / レジスタンス運動 / レジスタンストレーニング / マイオカイン

Outline of Final Research Achievements

Recently, it has been reported that the secretion of novel myokines involved in improving energy metabolism and insulin sensitivity was increased by hypoxia or resistance exercise. In this study, we focused on novel myokines whose secretion is stimulated by hypoxia or resistance exercise and investigated the effect of hypoxic resistance training on insulin sensitivity. Our results suggest that hypoxic resistance training may not affect the secretion of apelin and zinc-α2-glycoprotein, and may not affect the degree of resistance training-induced increase in insulin sensitivity.

Free Research Field

運動生理学

Academic Significance and Societal Importance of the Research Achievements

本研究の社会的意義は，低酸素レジスタンス運動・トレーニングが，エネルギー代謝やインスリン感受性の改善に関わる新規マイオカインの分泌およびインスリン感受性に及ぼす影響を明らかにし，肥満や糖尿病などの生活習慣病の予防・改善に役立つトレーニング法の開発につなげることであった．しかし，本研究において低酸素レジスタンス運動・トレーニングは，新規マイオカインであるapelinやzinc-α2-glycoproteinの分泌増加やインスリン感受性増加の程度に影響を及ぼさなかった．今後は，肥満者を対象として実験を行うなど，より詳細な検討が必要であると思われる．