Mechanisms of diminished endurance exercise effects and its solution

2023 Fiscal Year Final Research Report

• Project/Area Number: 20K11417
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 59020:Sports sciences-related
• Research Institution: The University of Electro-Communications
• Principal Investigator: Hoshino Daisuke 電気通信大学, 大学院情報理工学研究科, 准教授 (70612117)
• Project Period (FY): 2020-04-01 – 2024-03-31
• Keywords: PGC-1alpha / 乳酸 / 冷却 / シグナル伝達

Outline of Final Research Achievements

This study aimed to determine effects of cooling on contraction-induced peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) gene expression, phosphorylations of its related protein kinases, and metabolic responses. Male rats were separated into two groups; room temperature (RT) or ice-treated (COLD) on the right tibialis anterior (TA). The TA was contracted isometrically using nerve electrical stimulation. An increase in mRNA expression level of PGC-1α after muscle contractions was significantly lower in the COLD group than in the RT group. An increase in phosphorylated AMP-activated kinase (AMPK) and a decrease in glycogen concentration after muscle contraction were also significantly inhibited by cooling. Collectively, muscle cooling attenuated the post-contraction increases in PGC-1α mRNA expression coinciding with decreases in AMPK phosphorylation and glycogen degradation.

Free Research Field

運動生理生化学

Academic Significance and Societal Importance of the Research Achievements

本研究から，持久運動によって引き起こされるミトコンドリア生合成の分子メカニズムが冷却によって抑制されることが示唆された．このことは，運動前や運動中の筋温が運動効果に影響を与える可能性を示している．したがって，衣類による体温の調節や環境による筋温の変化に対する対応，適切なウォーミングアップなどが効率的なトレーニングの効果の獲得に重要であることを示唆している．