Therapeutic application of lifestyle-related diseases targeting mucosa-associated microbiota and mucosal barrier

2023 Fiscal Year Final Research Report

• Project/Area Number: 20K11513
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 59040:Nutrition science and health science-related
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: Katada Kazuhiro 京都府立医科大学, 医学(系)研究科(研究院), 准教授 (60593910)
• Co-Investigator(Kenkyū-buntansha): 高木 智久 京都府立医科大学, 医学(系)研究科(研究院), 准教授 (70405257)
• Project Period (FY): 2020-04-01 – 2024-03-31
• Keywords: 生活習慣病 / 粘膜関連細菌叢 / 粘膜バリア / 腸管粘膜上皮機能

Outline of Final Research Achievements

Gut microbiota is closely related to the pathogenesis and development of various diseases such as lifestyle diseases. There are many studies regarding the disruption of gut homeostasis due to the altered gut microbiota; however, mucosa-associated microbiota (MAM) and mucosal barrier are not fully investigated　in this field. Herein, in the present study , we demonstrated that the intestinal inflammation, mucosal barrier, gut microbiota and MAM were changed and controlled by water-soluble dietary fiber, heme oxygenase and carbon monoxide, ferroptosis inhibitor, and titanium dioxide in the models of non-alcoholic fatty liver, intestinal inflammation, and leaky gut syndrome.

Free Research Field

消化器病学、粘膜バリア学

Academic Significance and Societal Importance of the Research Achievements

生活習慣病などの様々な疾患の発症や進展に、腸内細菌叢の変容は密接に関連しており、腸内細菌叢を標的とした研究の進歩は凄まじい。一方、腸管粘膜上皮の恒常性に密接に関わる粘膜関連細菌叢や粘膜バリアについての研究は不十分である。本研究では、生活習慣病等のモデルを用い、水溶性食物繊維、一酸化炭素、鉄、酸化チタンによる、炎症制御機構や粘膜バリアへの影響、腸内細菌叢や粘膜関連細菌叢の変容について検討を行った。粘膜関連細菌叢や粘膜バリアを標的とした生活習慣病への治療応用につながる研究となった。