2022 Fiscal Year Final Research Report
Protection mechanism of citrus components against brain dysfunction using double congenic SHRSP/Izm
| Project/Area Number |
20K11523
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 59040:Nutrition science and health science-related
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| Research Institution | Matsuyama University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
並河 徹 島根大学, 学術研究院医学・看護学系, 特任教授 (50180534)
中島 光業 松山大学, 薬学部, 教授 (70311404)
澤本 篤志 松山大学, 薬学部, 准教授 (70760388)
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | SHRSP / 脳卒中 / 柑橘成分 |
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| Outline of Final Research Achievements |
The salt-sensitive "quantitative trait locus" suggested to be present on chromosomes 1 and 18 of stroke-prone spontaneously hypertensive rats (SHRSP) was crossed between SHRSP/Izm and SHR/Izm, and a double congenic line (SHRpch1_18) was established. We investigated the cerebroprotective effects of heptamethoxyflavone (HMF) and naringin (NGI) contained in citrus peel on SHRpch1_18. Analysis in the brain striatum showed that the microglial activation and decrease in the number of neurons seen in the high salt-loaded group was ameliorated in the NGI group.
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| Free Research Field |
神経薬理学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究では、食塩感受性QTLのダブルコンジェニックラット（SHRpch1_18）を用いた。我々はこれまで、柑橘果皮に含有されるheptamethoxyflavone (HMF)とnaringin（NGI）の脳保護作用に着目し研究を進めてきたことから、本研究ではSHRpch1_18に高食塩負荷を行い、HMFとNGIの効果について解析し、特にNGIで脳線条体のミクログリア活性化抑制作用と神経細胞死抑制作用を確認した。脳卒中病態を引き起こす可能性が示唆されている食塩感受性QTLに対し、改善効果が見込まれる化合物を示唆できたことは、脳卒中予防を考える上でも非常に有意義な知見である。
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