Multi-layered elucidation of the effects of exercise therapy for early metabolic syndrome

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K11526
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 59040:Nutrition science and health science-related
• Research Institution: National Cardiovascular Center Research Institute
• Principal Investigator: Tsuchimochi Hirotsugu 国立研究開発法人国立循環器病研究センター, 研究所, 室長 (60379948)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: メタボリックシンドローム / 運動療法 / 食餌療法 / エピゲノム修飾

Outline of Final Research Achievements

This study focused on epigenetic modifications due to environmental factors such as exercise and eating habits and the risk of developing metabolic syndrome, and examined epigenetic modifications during fetal and neonatal stages and modifications due to long-term lifestyle habits at the individual, organ, cellular, proteomic, and epigenomic levels.
In long-term high-fat-loaded mice, the effects of diet and exercise were synergistic in several genes involved in the development of metabolic syndrome, based on individual phenotype, cardiac function, glucose tolerance, gene and protein expression analysis, and open chromatin regions. It was suggested that the combination of the two is more beneficial than improvement of diet and exercise habits alone for prevention and early treatment of the onset of metabolic syndrome and lifestyle-related diseases.

Free Research Field

運動生理学

Academic Significance and Societal Importance of the Research Achievements

誰しも食事制限や定期的な運動によるカロリー消費を行うのを好まず、それが生活習慣病の蔓延に繋がっている。生活習慣病において、環境要因に起因する疾患、症状は予防や早期治療が可能であり、これまでも食事療法や運動療法が行われてきた。その効果について、近年では遺伝子・タンパク質発現の網羅的解析やエピゲノム修飾解析が普及し、それぞれの影響を多角的に解析可能となってきた。今回、食餌療法と運動療法、およびその組み合わせの影響を調べたことで、単独よりも組み合わせた方がより大きな効果を得られることが示唆された。今後、遺伝子発現制御機構の要因も加味することで、疾患に合わせて効果的な治療法の提案が可能となる。