Analysis of sensing of nutritional status and nutritional status-dependent modulation of gustatory transmission in the geniculate ganglion

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K11542
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 59040:Nutrition science and health science-related
• Research Institution: Asahi University
• Principal Investigator: Suwabe Takeshi 朝日大学, 歯学部, 准教授 (00610312)
• Co-Investigator(Kenkyū-buntansha): 安尾 敏明 朝日大学, 歯学部, 講師 (30608469)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 味覚 / レニン-アンジオテンシン系

Outline of Final Research Achievements

We investigated change in expression levels of renin-angiotensin system genes and angiotensin II receptor genes of rat geniculate ganglia in various situations. Their expression levels changed during development. Some developmental changes were common with trigeminal ganglia and others unique to geniculate ganglia. Their expression levels were also upregulated or downregulated with water deprivation, sodium-restriction, protein-restriction and diabetes. These results suggest that in the geniculate ganglion the renin-angiotensin system modulates taste information conveyed to the central gustatory system.

Free Research Field

歯科生理学

Academic Significance and Societal Importance of the Research Achievements

味覚は味覚嗜好性や食欲の形成を通じて摂食行動に関与する。したがって体内の栄養状態に応じた味覚情報伝達の調節メカニズムを解明する本研究は栄養状態に応じた摂食制御メカニズムの理解を深め、高齢者の摂食機能の低下や食欲不振による身体の衰えの予防、あるいは偏食や過食による生活習慣病の予防や改善につながることで健康寿命の延伸に貢献できると考えられる。