2022 Fiscal Year Final Research Report
Elucidating the pathogenic mechanisms of systemic diseases associated with oral microbiome
Project/Area Number |
20K11550
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 59040:Nutrition science and health science-related
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Research Institution | Tohoku University |
Principal Investigator |
Saito Sakae 東北大学, 未来型医療創成センター, 講師 (20335491)
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Project Period (FY) |
2020-04-01 – 2023-03-31
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Keywords | マイクロバイオーム |
Outline of Final Research Achievements |
The oral microbiome is closely linked to the triggering, development, and progression of systemic diseases by affecting host metabolism and immunity. The aim of this study was to elucidate the mechanisms of the pathogenic interaction between host and oral microbiome in diabetes and arteriosclerosis. We approached the oral microbiome profiling by using saliva biospecimens collected in the Tohoku Medical Megabank (TMM) cohort studies. Through 16S rRNA gene sequencing analysis and 16S absolute quantification of 200 participants, we showed differences in the microbial composition of saliva between hyperglycemia and healthy groups, and between hypercholesteremia and healthy groups. We also found that 9 and 6 microbial taxa indicated significant change of abundance in hyperglycemia group and hypercholesteremia group, respectively.
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Free Research Field |
分子生物学
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Academic Significance and Societal Importance of the Research Achievements |
ヒトマイクロバイオームは地域や生活習慣によって構成が異なることが報告されており、日本人集団のマイクロバイオームの特徴を明らかにすることは、疾患の地域差の理解や個別化予防へつながる有用な取り組みである。本研究の成果として、唾液から高血糖および高コレステロールに関連するバイオマーカー候補が明らかになったことにより、マイクロバイオームを標的としたリスク因子の同定や、新しい治療法および予防法の開発につながると期待できる。
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