Elucidation of nutritional and metabolic pathology in heart failure patients from the viewpoint of energy metabolism and intestinal microbiota

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K11554
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 59040:Nutrition science and health science-related
• Research Institution: Shiga University of Medical Science
• Principal Investigator: Sasaki Masaya 滋賀医科大学, 医学部, 教授 (40242979)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 心不全 / 栄養代謝病態 / 腸内環境 / 腸内細菌叢

Outline of Final Research Achievements

The subjects were 20 patients with heart failure who underwent inpatient treatment at a cardiology department. Positive correlations were observed between serum BNP levels and serum CRP or TNF-α levels, but neither was significant. We divided into two groups, BNP≧200 (severe group) and BNP<200 (mild group), Serun TNF-α and IL-6 levels tended to be high in high BNP group, but no significant difference was observed.
Decreased α-diversity (observed species and Chao1 index) was found in severe group. On the other hand, there was no difference in the β-diversity. In the phylum-level analysis, the severe group tended to have a lower occupancy rate of Firmicutes and Bacteroidetes compared to the mild group. Genus-level analysis showed that the severe group had high occupancy rates of Dickeya and Enterococcus, and decreased occupancy rates of Paraprevotella, Clostridium, and Butyricococcus.

Free Research Field

臨床栄養学

Academic Significance and Societal Importance of the Research Achievements

重症の心不全患者では、腸内細菌叢の調整が低下し、腸内環境が悪化している傾向が認められた。しかし、栄養状態との関連について明らかでなかった。