2022 Fiscal Year Final Research Report
Overall picture of vitamin transport revealed by transporter study
| Project/Area Number |
20K11592
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 59040:Nutrition science and health science-related
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| Research Institution | Kyoto Women's University |
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Principal Investigator |
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | ビタミン / 輸送 / トランスポーター |
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| Outline of Final Research Achievements |
We investigated the transporter proteins in order to reveal overall picture of vitamin transport. We have demonstrated that purified N-terminal region of NPC1L1 bind vitamin K and that ABCG5/ABCG8 transports vitamin K. Furthermore, it was suggested that ABCG5/ABCG8 interacts with α-TTP which is involved in the intracellular transfer of vitamin E.
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| Free Research Field |
生化学
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| Academic Significance and Societal Importance of the Research Achievements |
ビタミンKの排出トランスポーターを世界で初めて同定した。また、その他のビタミントランスポーターについても手掛かりを得て、輸送の実態が明らかとなった。研究成果は、ビタミンの効率的な吸収を可能にする食品、健康食品の開発や食生活の提案への応用も期待される。
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