2023 Fiscal Year Final Research Report
Understanding the molecular mechanisms of dietary restriction from the view of nutrients absorption
| Project/Area Number |
20K11596
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 59040:Nutrition science and health science-related
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| Research Institution | University of Toyama (2021-2023)
National Center for Geriatrics and Gerontology (2020) |
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Principal Investigator |
Akagi Kazutaka 富山大学, 学術研究部薬学・和漢系, 助教 (30794424)
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| Project Period (FY) |
2020-04-01 – 2024-03-31
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| Keywords | 老化 / 食餌制限 / グルタミン酸トランスポーター / ショウジョウバエ |
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| Outline of Final Research Achievements |
Dietary restriction (DR) is a robust environmental method to extend both life- and health-span in diverse organisms. However, the molecular mechanisms of DR in each tissue are not fully understood. We examined the role of amino acids transporters in the gut upon DR. We found that expression level of the glutamate transporters, dmGlut and Eaat1, are declined with age. On the other hand, DR upregulates these expressions and attenuates its age-dependent reduction. Furtermore, we found that gut-specific dmGlut as well as Eaat1 knockdown abrogates DR dependent lifespan extension. These results suggest that glutamate transporters in the gut play a crucial role for aging upon DR.
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| Free Research Field |
老化
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| Academic Significance and Societal Importance of the Research Achievements |
本研究では、加齢に伴い腸管におけるグルタミン酸トランスポーターの発現が低下することが明らかとなった。また、食餌制限による栄養介入によりその低下が抑制できることもわかった。今後、哺乳類を用いた解析が必要であるが、本研究により加齢に伴う低栄養状態の分子実態の一端が明らかにできたと考えている。この成果は、低栄養状態に付随したフレイルやサルコペニアの予防法開発へ繋がると期待している。
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