2022 Fiscal Year Research-status Report
Effects of fish consumption on clinical response to targeted therapies in Japanese and Spanish patients with rheumatoid arthritis
| Project/Area Number |
20K11597
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| Research Institution | Hokkaido University |
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Principal Investigator |
Amengual Olga 北海道大学, 医学研究院, 講師 (10636939)
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| Co-Investigator(Kenkyū-buntansha) |
渥美 達也 北海道大学, 医学研究院, 教授 (20301905)
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| Project Period (FY) |
2020-04-01 – 2024-03-31
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| Keywords | Rheumatoid arthritis / Diet / Fish consumption / n-3 PUFAs / Targeted Therapy |
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| Outline of Annual Research Achievements |
During the third year, we completed dietary assessments in patients with rheumatoid arthritis (RA) on treatment with targeted therapies using the brief self-administered diet history questionnaire and a detailed fish frequency questionnaire to assess the fish consumption in the previous month. Three hundred and thirty-three patients (218 Japanese, 115 Spanish) returned the questionnaires. Disease activity was evaluated at study entry and demographic, clinical and laboratory information was retrospectively collected. In the Japanese cohort, an analysis was performed in 124 patients with all clinical/laboratory data available. Ninety-six patients (77%) were responders to treatment. All patients had fish consumption in the last month and 82% reported intake of n-3 polyunsaturated fatty acids (PUFAs) rich fish (<1 time/week 33%, ≧1 time/week 49%). A higher estimated daily intake of n-3 PUFAs from fish was found in the responder group compared to the non-responder group [median gr, 1.01 (IQR 0.47-1.44) vs 0.51 (IQR 0.34-1.14), p=0.044]. The analysis of 62 patients from the Spanish cohort, thirty-four (55%) responders to treatment, revealed that all patients had consumption of fish in the last month and 77% had consumed n-3 PUFA rich fish (<1 time/week 31%, ≧1 time/week 46%). No difference in estimated intake of n-3 PUFAs from fish was observed in this cohort. These data suggest that fish consumption may have a positive effect on the response to treatment in Japanese RA patients receiving targeted therapies.
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| Current Status of Research Progress |
Current Status of Research Progress
3: Progress in research has been slightly delayed.
Reason
Due to the impact of the COVID-19 pandemic, the inclusion of patients in the retrospective phase of this study was delayed and we were unable to start the prospective study as planned. During this third year, the protocol and all prospective study materials were completed and approved by the ethics committee, and patient recruitment for the prospective phase was launched.
Regarding the prospective study, we have conducted an analysis of the effect of fish intake on the response to targeted therapy in the Japanese and Spanish RA cohorts and prepared and submitted abstracts to National and International Conferences. We are now completing the final analysis and will prepare the manuscript for publication.
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| Strategy for Future Research Activity |
We have secured an extension and in the fourth year we will recruit the patients for the prospective study, perform dietary assessments at the initial and subsequent visit and blood sampling. We will collect demographic; clinical and laboratory data at the two visits and perform the laboratory determinations. All data will be entered into the database and analysed. The results obtained in this research will be presented at national and international conferences and prepared for publication in academic journals.
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| Causes of Carryover |
Due to the delays we have experienced in the completion of the retrospective study, we have not been able to carry out the prospective phase of the study. We plan to use the funds for the development of the prospective study, including dietary analysis for the two visits, laboratory data measurements, data analysis and travel expenses to attend conferences and meetings with the Spanish counterpart.
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[Presentation] Intake of fish rich in n-3 polyunsaturated fatty acids is associated with good response to treatment in rheumatoid arthritis patients receiving targeted therapies.2022
Author(s)
Tarumi M, Amengual O, Fujieda Y, Navidad Fuentes M , Tsuchida N, Yasuda M , Nishino K , Kosumi Y, Takeyama S ,Yoshimura M, Ninagawa K , Aso K, Kono M, Kato M, Caliz Caliz R, Atsumi T.
Organizer
The Annual European Congress of Rheumatology (EULAR). Copenhagen, Denmark, 1-4 June 2022
Int'l Joint Research
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[Presentation] Dynamic functional connectivity associated with response to biologics in rheumatoid arthritis and spondyloarthritis.2022
Author(s)
Sakiyama K, Abe N, Fujieda Y, Tada M, Tsuchida N, Nishino K, Moriya H, Yasuda M, Kono M, Kato M, Amengual O, Atsumi T
Organizer
第66回日本リウマチ学会総会・学術集会、2022年4月25日～4月27日、横浜
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[Presentation] Functional MRIによる動的機能連関解析を用いた炎症性関節炎患者における治療効果予測2022
Author(s)
崎山広大, 阿部靖矢, 藤枝雄一郎, 多田麻里亜, 守谷悠, 安田充孝, 久田諒, 河野通仁, 加藤将, Olga Amengual, 渥美達也
Organizer
第37回日本臨床リウマチ学会、2022年10月29日、札幌
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