Effects of fish consumption on clinical response to targeted therapies in Japanese and Spanish patients with rheumatoid arthritis

2023 Fiscal Year Annual Research Report

• Project/Area Number: 20K11597
• Research Institution: Hokkaido University
• Principal Investigator: Amengual Olga 北海道大学, 医学研究院, 講師 (10636939)
• Co-Investigator(Kenkyū-buntansha): 渥美 達也 北海道大学, 医学研究院, 教授 (20301905)
• Project Period (FY): 2020-04-01 – 2024-03-31
• Keywords: Rheumatoid arthritis / Diet / Targeted therapy / Fish consumption / n-3 PUFAs

Outline of Annual Research Achievements

In the fourth year, we finalized the analysis of all patients included in the retrospective study. We included 205 rheumatoid arthritis (RA) patients from the Japanese cohort and 74 patients from the Spanish cohort. Analysis showed that among Japanese RA patients receiving molecular targeted therapies, responders had a higher estimated daily intake of n-3 polyunsaturated fatty acids (n-3 PUFA) compared to non-responders. Multivariate logistic regression analysis identified intake of n-3 PUFA rich fish at least once a week as an independent factor associated with improved outcomes. In the Spanish cohort, no difference in fish consumption was observed between responders and non-responders to molecular targeted therapies. We have finalized the manuscript and are preparing to send it to an international journal shortly after incorporating feedback and receiving approval from all co-authors.
We launched the prospective study phase, recruited a total of 50 RA patients who initiated a new targeted therapy and completed dietary assessments. Thirty-two patients completed the second visit after a 3-month follow-up to assess their response to treatment. Data from these visits have been collected and incorporated into the database. However, given the design of the study, the analysis will be completed at the conclusion of the data collection for the two visits of all patients.

Research Products

• [Int'l Joint Research] Hospital Virgen de la Nieves, Granada(スペイン)
  • Country Name: SPAIN
  • Counterpart Institution: Hospital Virgen de la Nieves, Granada
• [Journal Article] Itaconate ameliorates autoimmunity by modulating T cell imbalance via metabolic and epigenetic reprogramming (2023)
  • Author(s): Aso Kuniyuki、Kono Michihito、Kanda Masatoshi、Kudo Yuki、Sakiyama Kodai、Hisada Ryo、Karino Kohei、Ueda Yusho、Nakazawa Daigo、Fujieda Yuichiro、Kato Masaru、Amengual Olga、Atsumi Tatsuya
  • Journal Title: Nature Communications Volume: 14 Pages: 984
  • DOI: 10.1038/s41467-023-36594-x
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] Fish consumption influences treatment response in patients with rheumatoid arthritis on molecular targeted therapy (2024)
  • Author(s): Tarumi M, Amengual O, Yasuda M, Kosumi Y, Takeyama S, Hisada R, Kono M, Fujieda Y, Kato M, Atsumi T
  • Organizer: 第68回日本リウマチ学会総会・学術集会. International Concurrent Workshop.2024年4月18～ 20日,神戸
• [Presentation] The influence of dietary fish consumption in the treatment of rheumatoid arthritis. (2023)
  • Author(s): Amengual O
  • Organizer: Fourth meeting of the Association of Spanish Researchers in Japan. Tokyo, Japan, 4-5 November 2023
• [Presentation] Relationship between fish consumption and response to treatment with molecular targeted therapies in patients with rheumatoid arthritis. (2023)
  • Author(s): Tarumi M, Amengual O, Navidad Fuentes M, Yasuda M, Kosumi Y, Takeyama S, Yoshimura M, Ninagawa K , Aso K, Hisada R, Kono M, Fujieda Y, Kato M, Caliz R, Atsumi T
  • Organizer: The Annual European Congress of Rheumatology (EULAR). Milan, Italy, 31 May-3 June
  • Int'l Joint Research
• [Presentation] An endogenous metabolite, itaconate ameliorates collagen-induced arthritis by inhibiting fibroblast-like synoviocytes proliferation and migration (2023)
  • Author(s): Tada M, Kudo Y, Kono M, Sakiyama K, Takeyama S, Hisada R, Fujieda Y, Kato M, Amengual O, Atsumi T
  • Organizer: The Annual Meeting of the Federation of Clinical Immunology Societies, Boston, USA, 20 Jun, 2023
  • Int'l Joint Research
• [Presentation] The whole body MRI analysis of non-radiographic spondyloarthritis (SpA) and rheumatoid arthritis (RA) (2023)
  • Author(s): Kosumi Y, Aso K, Kato M, Hisada R, Kono M, Fujieda Y, Amengual O, Kamishima T, Atsumi T.
  • Organizer: 第67回日本リウマチ学会総会・学術集会、2023年 4月24日-4月26日
• [Presentation] An endogenous metabolite, itaconate ameliorates collagen-induced arthritis (2023)
  • Author(s): Kono M, Tada M, Kudo Y, Hisada R, Fujieda Y, Kato M, Amengual O, Atsumi T
  • Organizer: 第67回日本リウマチ学会総会・学術集会、2023年 4月24日-4月26日、福岡