2022 Fiscal Year Final Research Report
Development of novel disease markers focusing on ether-type phospholipids in chronic kidney disease
| Project/Area Number |
20K11598
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 59040:Nutrition science and health science-related
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| Research Institution | Iwate University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
内田 俊也 帝京大学, 医学部, 教授 (50151882)
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | エーテル型リン脂質 / 慢性腎臓病 |
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| Outline of Final Research Achievements |
A model of kidney disease induced by adenine ingestion was used. Adenine diet intake decreased choline-type alkyl phospholipids (Alk) and increased plasmalogens (Pls) in the kidneys. Furthermore, ex vivo experiments using chronic renal surface mouse kidneys on an adenine diet revealed that in kidneys damaged by adenine-induced injury, physical stimulation increased inflammation-related gene expression and ether-type phospholipid biosynthesis rate-limiting enzyme AGPS gene expression, while choline-type Alk was decreased and an increase in ethanolamine-type Pls, indicating an accelerated conversion of Alk to Pls, and revealing part of the response of ether-type phospholipids to stress.
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| Free Research Field |
脂質生理学
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| Academic Significance and Societal Importance of the Research Achievements |
腎臓病におけるストレスに対応するエーテル型リン脂質の関与を示唆する結果を得た。この結果は、エーテル型リン脂質の新たな生理機能を提案するとともに、ヒトの健康に大きく寄与しうるものである。
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