Comprehensive study of risk factors and biomarkers that contribute to elucidation of the pathology of renal disorders due to aging and lifestyle

2023 Fiscal Year Final Research Report

• Project/Area Number: 20K11599
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 59040:Nutrition science and health science-related
• Research Institution: Chiba University
• Principal Investigator: Masaya Koshizaka 千葉大学, 予防医学センター, 准教授 (30466700)
• Co-Investigator(Kenkyū-buntansha): 竹本 稔 国際医療福祉大学, 医学部, 主任教授 (60447307) ; 前澤 善朗 千葉大学, 大学院医学研究院, 講師 (80436443)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 早期腎機能障害 / 予測危険因子 / 特定健診 / BMI / HbA1c / 歩行習慣

Outline of Final Research Achievements

To identify predictive risk factors for early renal dysfunction, we analyzed specific health examination data from the general Japanese population. The composite endpoint was progression of renal dysfunction over 6 years, including doubling of serum creatinine level, 30% and more decrease in eGFR, and 30% and more increase in urine albumin/creatinine ratio (UACR), for participants with UACR 30 mg/gCre and more at baseline. Progression to UACR 30 mg/gCre and more for participants with UACR <30 mg/gCre at baseline.
Results, BMI, HbA1c, and walking habits were significantly associated with progression of renal dysfunction. In conclusion, higher BMI and HbA1c and less walking habits were associated with earlier renal dysfunction in the general population.

Free Research Field

糖尿病・代謝・内分泌内科学

Academic Significance and Societal Importance of the Research Achievements

検診受診者における早期腎機能障害の予測危険因子を明らかとすることが出来た。これにより今後、より予防や介入が必要な受診者を早期に検出することが可能となる。また予測危険因子が、BMI、HbA1c、歩行習慣であったことより、介入可能な内容であり、より検診の意義を高めることができる。
早期腎機能障害を予防することにより、医療費や医療資源の節約に繋がる。