Identificaiton of nutritional factors which suppresses SASP

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K11634
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 59040:Nutrition science and health science-related
• Research Institution: Sugiyama Jogakuen University
• Principal Investigator: Noboru Motoyama 椙山女学園大学, 生活科学部, 教授 (50277282)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 細胞老化 / SASP / 炎症 / 老年病 / 食品

Outline of Final Research Achievements

Senescent cells accumulate during aging and secrete several factors such as pro-inflammatory cytokines. This phenomenon is known as the Senescence-Associated Secretory Phenotype (SASP). It has been reported that SASP is involved in the development of geriatric diseases. Due to the potential of inhibiting SASP to delay the onset of these diseases, it serves as a potential target for their prevention. In this study, our aim was to elucidate the mechanism of SASP and explore bioactive factors derived from natural products for the prevention of SASP.

Free Research Field

分子細胞生物学

Academic Significance and Societal Importance of the Research Achievements

老化細胞を特異的に除去する（Senolysis）薬剤の開発が進み、Senolysisによって老年性疾患の発症が遅延し、平均寿命が延長することが示されてきた。本研究でSASP誘導時に発現が変化する遺伝子産物を同定した。また、SASPを抑制する種々の食品由来抽出液の同定を行った。これの研究を通して、SASPをターゲットとした老年病発症の予防方法を開発する基盤となると考えられる。