Cancer chemoprevention by using diarylpentanoid analog of curcumin as a functional food

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K11643
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 59040:Nutrition science and health science-related
• Research Institution: Akita University
• Principal Investigator: Shibata Hiroyuki 秋田大学, 医学系研究科, 教授 (50260071)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: クルクミン / 制御性T細胞 / 腫瘍免疫 / 機能性食品 / GO-Y022 / 2-deoxy-d-glucose

Outline of Final Research Achievements

Regulatory T cells (Treg) can suppress tumor immunity negatively. Pyrolyzed curcumin analog, GO-Y022 is included in food, and can suppress Treg differentiation at 250 nM. Oral administration of GO-Y022 could significantly inhibit gastric cancer growth in the mouse models, where the percentage of Treg was not influenced. This phenomenon was due to the production of lactate from cancer cells. For this inhibition, we used 2-deoxy-d-glucose (2DG) together with GO-Y022, inhibiting Treg induction. As 2DG is an analog of glucose, it is also safe. We can use GO-Y022 with 2DG as a functional food to induce tumor immunity.

Free Research Field

腫瘍免疫

Academic Significance and Societal Importance of the Research Achievements

クルクミンの熱変性体であるGO-Y022、そしてグルコースの誘導体である2-deoxy-d-glucoseを併用することで胃癌細胞からの乳酸産生を抑制して制御性T細胞の分化誘導を抑制できることが示された。この低毒性で、食用可能な化合物を機能性食品として用いることで、胃癌細胞と免疫細胞のクロストークを遮断する。こうして、腫瘍が存在する微小環境における負のスパイラルを断ち切ることに成功した。このような毒性のない食品でがん薬物療法や化学発がん予防が実現できる可能性が示された。