Effects of Exercise on the Oral Microbiota and Saliva of Patients With Non-Alcoholic Fatty Liver Disease

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K11644
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 59040:Nutrition science and health science-related
• Research Institution: University of Tsukuba
• Principal Investigator: Uchida Fumihiko 筑波大学, 医学医療系, 講師 (70736008)
• Co-Investigator(Kenkyū-buntansha): 鈴木 英雄 筑波大学, 医学医療系, 准教授 (00400672) ; 呉 世昶 アール医療専門職大学, リハビリテーション学部, 教授 (10789639) ; 岡田 浩介 筑波大学, 医学医療系, 准教授 (80757526) ; 正田 純一 筑波大学, 医学医療系, 客員教授 (90241827)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 肥満 / NAFLD / 歯周病 / 運動療法 / 口腔内細菌叢 / メタゲノム解析

Outline of Final Research Achievements

Biochemical and genetic analyses on saliva from overweight men with NAFLD and gum disease were done before and after 12-week exercise or diet programs. Importantly, we found that reductions in lactoferrin, lipopolysaccharide, and IgA concentrations were only evident in the men who followed the exercise regimen. The exercise group also showed increased bacterial diversity and changes in the relative constituent bacterial populations. In the overall population, more bacteria expressed genes related to environmental information processing, and less bacteria expressed genes related to genetic information processing and metabolism. In fact, bacteria expressed fewer genes for producing lipopolysaccharides.
It seems that, in people with both non-alcoholic liver disease and gum disease, exercise causes a biochemical shift in the environment of the mouth that favors the survival of less harmful bacteria.

Free Research Field

健康応用科学

Academic Significance and Societal Importance of the Research Achievements

本研究により, NAFLD肥満者について, 運動療法が口腔内の細菌叢の構成や唾液成分の変化を介して歯周病の改善をもたらすことが実証され, 肥満者, 糖尿病, 高齢者など歯周病の高リスクグループに対する健康管理の一環として, 運動療法の重要性がより明確になったと言うことが出来る.