2022 Fiscal Year Final Research Report
Maternal quercetin or curcumin intake during lactation affects to inflammation and autophagy of skeletal muscles of high fat-fed rat offspring programmed by maternal protein restriction.
| Project/Area Number |
20K11649
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Review Section |
Basic Section 59040:Nutrition science and health science-related
|
|---|
| Research Institution | Aomori University of Health and Welfare |
|---|
Principal Investigator |
Sato Shin 青森県立保健大学, 健康科学部, 教授 (40310099)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
向井 友花 神奈川県立保健福祉大学, 保健福祉学部, 教授 (60331211)
山岡 伸 青森県立保健大学, 健康科学部, 実験・実習助手 (40830823)
|
|---|
| Project Period (FY) |
2020-04-01 – 2023-03-31
|
| Keywords | 胎生期低栄養 / 植物ポリフェノール / 骨格筋 / 慢性炎症 / オートファジー |
|---|
| Outline of Final Research Achievements |
Maternal undernutrition is associated with the impairment of the development of skeletal muscles in offspring. We investigated the effects of plant delivered polyphenols such as quercetin and curcumin intake during lactation on inflammation and autophagy in the gastrocnemius muscles (GMs) of high-fat diet (HFD)-fed offspring programmed by maternal protein restriction. Quercetin intake during lactation enhanced the increased macrophage number and fibrosis-related cytokine level and the decreased autophagy markers in the GMs of adult offspring. When given curcumin during lactation, the macrophage number and fibrosis area ratio decreased in the GMs. The autophagy markers were increased. Taken together, quercetin and curcumin intakes during lactation may have different function in the GMs of HFD-fed adult offspring programmed by maternal protein restriction.
|
| Free Research Field |
栄養生化学
|
| Academic Significance and Societal Importance of the Research Achievements |
本研究の学術的意義は、妊娠期・授乳期に低栄養に曝された母ラットの授乳期に植物ポリフェノール（PP）を摂取させると、離乳後に高脂肪食負荷した仔ラットの骨格筋に及ぼす影響がPPの種類によって異なる可能性があることを示した点にある。例えば、乳児期にクルクミンを摂取した仔の腓腹筋では、成長後の高脂肪食負荷により生じる骨格筋における炎症や線維化を、オートファジーを介して軽減することを示した。本研究の結果は、発育初期に摂取するPPの種類によっては早期医療・早期介入とする「先制医療」を見据えた予防策に寄与する可能性がある。
|
