2020 Fiscal Year Research-status Report
Computer modeling of cardiac conduction system for arrhythmia research and implantable device testing
| Project/Area Number |
20K12046
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| Research Institution | The University of Aizu |
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Principal Investigator |
Maxim・V Ryzhii 会津大学, コンピュータ理工学部, 上級准教授 (50254082)
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | Mitchell-Schaeffer / Corrado-Niederer / Aliev-Panfilov / pacemaker / nonlinear equation / dual pathway / oscillator / cardiac model |
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| Outline of Annual Research Achievements |
1. We investigated the effect of different sinusoidal AC signals on the atrioventricular node function during atrial fibrillation. We used our nonlinear MATLAB/Simulink model incorporating dual pathway physiology based on nonlinear differential equations. The results demonstrated that, depending on amplitude and
frequency, external AC signals can noticeably change the atrioventricular node performance. The results confirmed that our proposed dual-pathway model can be useful for investigation of atrial fibrillation rate control methods.
2. We used minimal two-variable models - Mitchell-Schaeffer and Corrado-
Niederer, and four-variable Bueno-Orovio-Cherry-Fenton model to investigate the possibility to obtain an onset of ectopic activity in border zones between normal and damaged myocardial tissue. For the simulations of damaged tissue we used bistable and ultra-long action potentials of cardiomyocytes. We performed a nonlinear analysis of the conditions required for the ectopic activity onset. We concluded that modified Mitchell-Schaeffer and Corrado-Niederer cardiac models can be utilized in our atrioventricular dual-pathway model as both excitable and pacemaking elements. We developed oscillating variants Mitchell-Schaeffer, Corrado-Niederer, and Aliev-Panfilov simplified cardiac cell models, and performed their analysis. Two conference papers were published. The research paper under preparation. Pertinent software for MATLAB was developed. The developed models will be used as pacemakers in our atrioventricular dual-pathway model.
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| Current Status of Research Progress |
Current Status of Research Progress
2: Research has progressed on the whole more than it was originally planned.
Reason
We faced some difficulty creating simple quasi-3D models for cardiac muscles able to produce adequately full 12 lead ECG signals in the replacement of our previous simplified muscle description with FitzHugh-Nagumo equations.
However, we managed to develop novel models for cardiac (and for other organs) natural pacemakers based on conventional excitable models.
Also, some types of arrhythmias were simulated using modified cardiac cell models.
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| Strategy for Future Research Activity |
We will continue to improve our atrioventricular dual-pathway model with inclusion of novel developed excitable and pacemaker models, allowing uniform and simplified description.
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| Causes of Carryover |
Due to COVID19 situation, travel to international conferences was prohibited and
purchase of some project-related items was restricted. We are going to spent the incurring amount for hardware and research papers publication fees, in particular.
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