2021 Fiscal Year Research-status Report
Computer modeling of cardiac conduction system for arrhythmia research and implantable device testing
| Project/Area Number |
20K12046
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| Research Institution | The University of Aizu |
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Principal Investigator |
Maxim・V Ryzhii 会津大学, コンピュータ理工学部, 上級准教授 (50254082)
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | Corrado-Niederer / Aliev-Panfilov / "natural pacemaker" / "nonlinear equation" / "dual pathway" / "cardiac model" / intestine / "sinoatrial node" |
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| Outline of Annual Research Achievements |
1. We performed basic bifurcation analysis of complex ion-channel and simplified cardiac pacemaker models available in the CellML Model Repository and compared their responses. The observed bifurcation behavior demonstrated pronounced differences among the models. Only a few of the models exhibited Hodgkin-Huxley-like general dynamics. We concluded that a suitable pacemaker cell model should be able to operate in a wide range of applied external currents, which can guarantee their sustained self-oscillations in different modeling situations. These results were presented online and published in the conference proceedings.
2. We developed oscillating variants Aliev-Panfilov (AP) and Corrado-Niederer (CN) two-variable excitable cardiac cell models.
We conducted a numerical simulation study of these models and investigated the nonlinear dynamic features. We also developed computer models of the 2D sinoatrial node (2D SAN) with exit pathways and 3D intestine tissue. We calculated activation sequences for the SAN model variants with and without exit pathways. In the 3D intestine simulations, we observed slow waves in interstitial cells of Cajal traveled distally along the small intestine, formations of plateaus with constant frequency, and initiation of dysrhythmia due to temporary conduction block. Our obtained results are similar to clinical, experimental, and simulation data.
The developed software in MATLAB and CellML was published in GitHub open source repository. A research paper was published on BioRxiv preprint site and is in press (published in a journal in April 2022).
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| Current Status of Research Progress |
Current Status of Research Progress
3: Progress in research has been slightly delayed.
Reason
We developed pacemaking variants of two-variable excitable cardiac cell models (Aliev-Panfilov and Corrado-Niederer models) which can replace FitzHugh-Nagumo equations in different modeling situations. The complex functional atrioventricular node model for rabbit heart including the dual pathway based on the developed pacemaking Aliev-Panfilov model is under construction.
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| Strategy for Future Research Activity |
We will finish the development of the functional atrioventricular node (AVN) model for rabbit heart on the base of Aliev-Panfilov model,
able to reproduce almost all physiological functions and features of the AVN. Pertinent MATLAB software is under development.
We will propose an improved version of Mitchell-Schaeffer excitable and pacemaking models, and compare its nonlionear features with the Corrado-Niederer model. The improved model is expected to be used in the cardiac conduction system model of human heart. With these studies, we will continue creating simple quasi-3D models for cardiac muscles able to produce adequately full 12 lead ECG signals.
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| Causes of Carryover |
Due to COVID19 situation, travel to international conferences was prohibited and purchase of some project-related items was restricted. We are going to spent the incurring amount for open publications of research papers and conference fees, in particular.
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Research Products
(5 results)
