A novel role of Plectin in ionizing radiation-induced DNA damage response

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K12170
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 63020:Radiation influence-related
• Research Institution: Kanazawa Medical University
• Principal Investigator: MATSUI Tadashi 金沢医科大学, 医学部, 助教 (60288272)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: DNA損傷応答 / Plectin

Outline of Final Research Achievements

Plectin is known to connect the components of cytoskeletons to maintain cell structure. In this study, we elucidated a novel role of Plectin in the cellular response after DNA damage. ATM, which is activated by ionizing radiation-induced DNA double-strand breaks, regulates cell cycle arrest, DNA repair, and cell death by phosphorylating numerous target proteins. We newly found that Plectin is one of such ATM target proteins and that Plectin regulates the activation of the tumor suppressor p53 through binding to 53BP1, thereby playing a role in cell cycle arrest after DNA damage.

Free Research Field

分子細胞生物学

Academic Significance and Societal Importance of the Research Achievements

放射線は、空から降り注ぐ宇宙線や、医療用のレントゲンやCTスキャンなどごく身近に存在しているものであるが、近年、原発事故による放射能漏れ等の報道により、放射線の人体に与える影響について社会的な関心が高まっている。本研究により、放射線照射後に代表的な癌抑制因子であるp53が活性化される際の新たな制御機構の一端が明らかになった。本研究の成果は、放射線の人体に与える影響の全容解明につながることが期待される。