Seasonal fluctuation and regional characteristics of epigenetic induction via miRNA by airborne particles

2023 Fiscal Year Final Research Report

• Project/Area Number: 20K12195
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 63040:Environmental impact assessment-related
• Research Institution: Osaka Medical and Pharmaceutical University (2021-2023); Osaka University of Pharmaceutical Sciences (2020)
• Principal Investigator: Hasei Tomohiro 大阪医科薬科大学, 薬学部, 准教授 (10388027)
• Co-Investigator(Kenkyū-buntansha): 奥平 桂一郎 大阪医科薬科大学, 薬学部, 教授 (10425671) ; 鳥羽 陽 長崎大学, 医歯薬学総合研究科(薬学系), 教授 (50313680)
• Project Period (FY): 2020-04-01 – 2024-03-31
• Keywords: 環境 / エピジェネティクス

Outline of Final Research Achievements

Airborne particles were collected weekly in Japan, and the average of airborne particle concentration on each season was calculated as Spring (March, April, May), Summer (June, July, August), Autumn (September, October, November), and Winter (December, January, February). The averages of airborne particle concentration on Spring and Winter were higher than those on Summer and Autumn. The most of the airborne particle concentrations on Summer were corresponding to those on Autumn, however, the airborne particle concentrations on a few samples on Summer were dramatically high. These results suggested that some events, like volcano, had happened in the Summer.

Free Research Field

環境

Academic Significance and Societal Importance of the Research Achievements

本研究課題の執行期間の全期間にわたって、コロナ禍による屋内での研究に制約を受けたものの、大気粉塵の捕集は屋外での活動であるためほとんど制約を受けずに実施できた。期間中に捕集した試料には、火山噴火や黄砂の飛来などのイベントの影響を受けたと思われる試料があり、今後の研究の遂行に伴い、エピジェネティクス誘発活性の季節変動だけでなく、火山噴火や黄砂によるエピジェネティクス誘発活性への影響を明らかにすることができる。これらについての知見はこれまでに得られておらず、国民衛生の向上に大きく寄与できる。