2022 Fiscal Year Final Research Report
Elucidation of the pathogenesis of idiopathic pulmonary fibrosis by ion beam engineering technology
Project/Area Number |
20K12493
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 80040:Quantum beam science-related
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Research Institution | Gunma University |
Principal Investigator |
Koga Yasuhiko 群馬大学, 大学院医学系研究科, 助教 (10533862)
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Co-Investigator(Kenkyū-buntansha) |
佐藤 隆博 国立研究開発法人量子科学技術研究開発機構, 量子ビーム科学部門, 研究統括(定常) (10370404)
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Project Period (FY) |
2020-04-01 – 2023-03-31
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Keywords | 特発性肺線維症 / 特発性間質性肺炎 / PIXE / シリカ / 環境 / PM2.5 |
Outline of Final Research Achievements |
In this study, elemental analysis by in-air micro-PIXE revealed that the lung tissue of idiopathic pulmonary fibrosis contains a high amount of crystalline silica and that disease progression in idiopathic pulmonary fibrosis is faster in proportion to the amount of silica in the lung tissue. We also found that patients with high levels of silica in the lungs had shorter survival times than those with low levels. We are the first to show that inhaled silica from the environment is involved in the progression of pulmonary fibrosis and contributes to poor prognosis and outcome. This study clarifies the involvement of environmental factors, including silica, in idiopathic pulmonary fibrosis and provides avenues for public health prevention measures against environmental exposures and new therapeutic strategies for crystalline silica.
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Free Research Field |
Respiratory Medicine
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Academic Significance and Societal Importance of the Research Achievements |
臨床的に期待される成果: 特発性肺線維症におけるシリカの蓄積・分布を明らかにすることで、特発性肺線維症の病因を解明する新たな道筋となる。 さらに、体内へのシリカ暴露の遮断や、体内でシリカをキレートするための新たな治療戦略の開発へとつながる。 社会的に期待される成果: 特発性肺線維症の病因におけるシリカが果たす役割への理解を深めることで、シリカ暴露を制限する公衆衛生の取り組みや職場の安全基準に役立つ可能性が期待される。また今後の研究において、特発性肺線維症に関する今後の疫学調査や臨床研究へのまったく新しい基盤の提供となり得る。特に、その病因における環境要因の役割に焦点を当てた画期的な研究となる。
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