2022 Fiscal Year Final Research Report
Mechanisms of adipose tissue hypertrophy and fibrosis in lymphedema
| Project/Area Number |
20K12593
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 90110:Biomedical engineering-related
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| Research Institution | Chiba University |
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Principal Investigator |
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | リンパ浮腫 / 脂肪細胞 / 肥大化 / 脂肪滴 / 線維化 |
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| Outline of Final Research Achievements |
In lymphedema, the mechanisms underlying the hypertrophy and fibrosis of adipocytes, which constitute the adipose tissue, remain unclear. Therefore, in this study, we attempted to elucidate the effects of fatty acids on adipocyte lipid accumulation and collagen secretion. As a result, high concentrations of fatty acids were found to induce increased lipid accumulation and enlarged lipid droplets, potentially promoting the hypertrophy of adipose tissue in lymphedema. Furthermore, elevated levels of fatty acids were shown to increase collagen production and alter the collagen structure of preadipocytes, suggesting a potential role in promoting fibrosis in adipose tissue.
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| Free Research Field |
バイオメカニクス
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| Academic Significance and Societal Importance of the Research Achievements |
リンパ浮腫は，リンパ節切除を伴う婦人科がん手術後の患者に多く発症し，ひとたび発症すると完治しない．そのため，がんサバイバーのQOL 向上には，リンパ浮腫治療法の確立が必須である．本研究では，皮膚下の脂肪組織を構成する脂肪細胞において，脂肪酸が肥大化および線維化メカニズムにおよぼす影響を明らかにした．この結果は，リンパ浮腫患部にみられるむくみや線維化に対する治療法の確立にあたり重要な知見であり，リンパ浮腫治療法確立の観点から本研究成果の学術的意義および社会的意義は大きい．
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