Efficient DDS using biological nanoparticles hybridized with gluco-prodrugs

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K12650
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 90120:Biomaterials-related
• Research Institution: Oita University
• Principal Investigator: Shimoda Kei 大分大学, 医学部, 准教授 (40284153)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: バイオナノカプセル / プロドラッグ

Outline of Final Research Achievements

Utility of carriers of of lipid bilayer membrane has become issue in development of efficient drug delivery system. To solve the problem, production of prodrugs and their hybridization with carriers of lipid bilayer membrane for generation of a new drug delivery system were examined. Prodrugs were successfully synthesized from anti-cancer compounds. They showed satisfactory fitting with lipid bilayer membrane-carriers. These results contribute to the development of an efficient drug delivery system.

Free Research Field

DDS

Academic Significance and Societal Importance of the Research Achievements

近年、薬物の副作用を抑えるため、DDSの開発が盛んにおこなわれている。しかし、脂質二重膜から成るバイオナノカプセル(脂質二重膜リポソーム)の使用は、薬物との低い親和性のため、DDSの輸送効率の低下を引き起こすことから、この問題の解決策が求められてきた。本研究では、バイオナノカプセル（脂質二重膜リポソーム）と配糖体プロドラッグを組み合わせたハイブリッドな新規な薬物送達システムを開発する成果を得た。