2022 Fiscal Year Final Research Report
Development of a vascular composite organoid for highly efficient cell transplantation
| Project/Area Number |
20K12653
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 90120:Biomaterials-related
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| Research Institution | Tokyo University of Science |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
西川 元也 東京理科大学, 薬学部薬学科, 教授 (40273437)
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | 細胞移植治療 / オルガノイド / 血管コンポジット / ヒトiPS細胞 / 血管内蔵シート |
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| Outline of Final Research Achievements |
Cell transplantation therapy is a treatment method in which living cells are transplanted into patients, and is expected to be a next-generation therapy because of its excellent therapeutic effects. However, it has been reported that cells transplanted into a living body rapidly disappear, so it is necessary to improve the efficiency of cell transplantation for effective cell transplantation therapy. In this study, vascular composite three-dimensional cellular structures were fabricated for organoids, which were known to exhibit tissue-like functions and structures, to improve the survival after transplantation. Based on some experiments, we successfully developed a vascular composite cell sheet consisted of mesenchymal stem cells and blood endothelial cells, and the survival of a cell sheet after transplantation was improved.
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| Free Research Field |
細胞治療、再生医療、薬剤学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究では、細胞移植効率を格段に改善する方法として、血管構造を内蔵する細胞構造体の開発に成功した。本研究は、細胞移植において解決すべき細胞の移植効率を改善する極めて重要な内容であり、本研究で開発した技術は細胞移植治療の有効性を劇的に向上するものと期待される。本研究成果が実用化されることで、細胞移植治療の発展に寄与でき、医療の発展を介して社会へ貢献できると考える。これまでに、細胞移植治療における移植細胞の生存率を制御しようとする試みは少なく、細胞治療やオルガノイド研究において新たな可能性を生み出す点で学術的に意義深いものである。
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