Development of non-invasive thermometry utilizing magnetic nanoparticles in magnetic hyperthermia

2023 Fiscal Year Final Research Report

• Project/Area Number: 20K12663
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 90130:Medical systems-related
• Research Institution: Akita University
• Principal Investigator: Yamamoto Yoshiyuki 秋田大学, 理工学研究科, 准教授 (70322120)
• Project Period (FY): 2020-04-01 – 2024-03-31
• Keywords: 磁性ナノ粒子 / 磁気ハイパーサーミア / 温度測定 / 非侵襲

Outline of Final Research Achievements

Magnetic hyperthermia, in which magnetic nanoparticles accumulated in a tumor are heated by applying an alternating magnetic field to generate heat, is being investigated for non-invasive cancer treatment to improve the quality of life of patients. In this study, we developed a method to estimate the temperature of iron oxide nanoparticles from their magnetic signals in a non-contact manner and a method to control the temperature at a constant level while applying an alternating magnetic field to the particles and heating them. As a result, it was found that the temperature of sample can be estimated with an error of about 0.2 degree and that the temperature of sample can be controlled at constant temperature by applying DC magnetic field superimposed on an AC magnetic field.

Free Research Field

磁性

Academic Significance and Societal Importance of the Research Achievements

ハイパーサーミア治療では腫瘍部を加温して一定温度に保つ必要があるが，これまでに提案されている手法では，腫瘍温度を監視するために温度センサーを刺入しなければならず，QOL向上の利点である非侵襲性が失われてしまう問題点があった。本研究によって，非侵襲性を保ったままハイパーサーミア治療を実現するための手法の要素技術を構築することができた。