2023 Fiscal Year Final Research Report
Development of a numerical model to clarify the rupture/damage mechanics of the red blood cell
| Project/Area Number |
20K14651
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 19010:Fluid engineering-related
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| Research Institution | Iwate Prefectural University (2022-2023)
Akita Prefectural University (2020-2021) |
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Principal Investigator |
NIX Stephanie 岩手県立大学, ソフトウェア情報学部, 講師 (00756637)
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| Project Period (FY) |
2020-04-01 – 2024-03-31
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| Keywords | 赤血球 |
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| Outline of Final Research Achievements |
In this study, we developed a new numerical model that accurately reproduces the microstructure of red blood cell membranes to elucidate the mechanisms behind red blood cell rupture and damage. This model considers the complex structure of the cell membrane cytoskeleton, allowing for more realistic simulations compared to conventional models. Our findings have the potential to contribute to the improvement of medical devices such as artificial hearts and dialysis machines, potentially reducing the burden on patients. Additionally, this research is expected to advance basic research on red blood cells.
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| Free Research Field |
計算生体力学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究で開発した赤血球膜のモデルは，赤血球の破壊メカニズムの解明に貢献する．これは学術的に重要な進展であり，血液に関する基礎研究を前進させる．社会的には，この知見を活用することで，人工心臓や透析装置などの医療機器の設計改良が可能となり，溶血（赤血球の破壊）のリスクを低減できる．結果として，これらの機器を使用する患者さんの安全性と生活の質の向上につながると期待される．
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