Development of a Smartphone Biosensor for Simultaneous Measurement of Multiple Biomarkers

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K14748
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 21030:Measurement engineering-related
• Research Institution: Tokyo Institute of Technology
• Principal Investigator: Toma Mana 東京工業大学, 工学院, 准教授 (20756697)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: バイオセンサ / プラズモニクス

Outline of Final Research Achievements

This research aimed to develop a biosensor that can rapidly, sensitively, and quantitatively detect biomolecules related to disease and health conditions using a smartphone camera.　 Metal nanodome arrays were investigated as biosensor substrates, that change the surface colors by binding target biomolecules. The proof of concept of the colorimetric plasmonic biosensor using metal nanodome arrays was demonstrated. As the results, model immunoassay experiments showed that the colorimetric method provides a sensing performance as high as that by a conventional spectroscopic method. Furthermore, when evaluating the detection performance of nerve-specific enolase, one of the tumor markers, a direct detection method without a signal enhancement scheme such as fluorescent labeling successfully detected the target at the diagnostic level.

Free Research Field

プラズモニクス

Academic Significance and Societal Importance of the Research Achievements

本研究の遂行により、従来測定に必要であった分光器や光源を用いず、汎用のカラーカメラで高感度な生体分子検出が可能なプラズモニックバイオセンサの実証に成功した。これにより、プラズモニックバイオセンサの実用化が前進したといえる。本研究で開発した比色型のプラズモニックバイオセンサは、スマートフォンとの親和性が高く、将来的にはモバイルヘルス応用などが期待される。