2020 Fiscal Year Research-status Report
On-chip chiral biosensor based on superchiral-field-enhanced Raman optical activity
| Project/Area Number |
20K14785
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Xiao Tinghui 東京大学, 大学院理学系研究科(理学部), 助教 (50869675)
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | silicon photonics / optical biosensor / Raman spectroscopy |
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| Outline of Annual Research Achievements |
We demonstrated a novel on-chip biosensor, which is composed of a metal-free (i.e., without localized surface plasmon resonance), topologically tailored porous carbon nanowires in an array to overcome the unreliability of surface-enhanced Raman spectroscopy (SERS) for biomedical use. Specifically, the biosensor offers not only high signal enhancement (~1,000,000) due to its strong broadband charge-transfer resonance, but also extraordinarily high reproducibility due to the absence of hot spots. In addition, the biosensor exhibits high durability due to no oxidization and high compatibility to biomolecules due to its fluorescence quenching capability. The biosensor is expected to lead to high reliability of SERS for practical use.
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| Current Status of Research Progress |
Current Status of Research Progress
1: Research has progressed more than it was originally planned.
Reason
We demonstrated a novel on-chip biosensor based on surface-enhanced Raman spectroscopy this fiscal year, which is more smoothly than initially planned.
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| Strategy for Future Research Activity |
Based on the design, fabrication, and characterization experience we have accumulated for developing the on-chip biosensor based on surface-enhanced Raman spectroscopy this fiscal year, we will go further to realize the on-chip chiral biosensor based on Raman optical activity by optimizing the design and the characterization system of the biosensor in the following years.
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| Causes of Carryover |
Due to the COVID-19, some article costs and travel expenses could not be used as my previous plan. I will rearrange and use this incurring amount in the next fiscal year to help further accelerate the progress of this research project.
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