On-chip chiral biosensor based on superchiral-field-enhanced Raman optical activity

2022 Fiscal Year Annual Research Report

• Project/Area Number: 20K14785
• Research Institution: The University of Tokyo
• Principal Investigator: Xiao Tinghui 東京大学, 大学院理学系研究科(理学部), 客員共同研究員 (50869675)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: silicon photonics / optical biosensor / Raman spectroscopy

Outline of Annual Research Achievements

We successfully achieved several on-chip biosensors. The biosensors enable reliable, high-sensitivity measurement of biomolecules and cells with negligible artifacts. This is enabled by the tailored optical fields in the biosensors. We used the biosensors to show >100x enhanced light-matter interaction with negligible artifacts. The proposed biosensors are expected to open up a reliable, high-content, high-sensitivity way for analysis of biomolecules.

Research Products

• [Journal Article] Studying the efficacy of antiplatelet drugs on atherosclerosis by optofluidic imaging on a chip (2023)
  • Author(s): Deng Yunjie、Tay Hui Min、Zhou Yuqi、Fei Xueer、Tang Xuke、Nishikawa Masako、Yatomi Yutaka、Hou Han Wei、Xiao Ting-Hui、Goda Keisuke
  • Journal Title: Lab on a Chip Volume: 23 Pages: 410～420
  • DOI: 10.1039/D2LC00895E
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Ultracompact Vernier-effect-improved sensor by a single microfiber-knot resonator (2023)
  • Author(s): Yu Yang、Yu Ya-Nan、Chen Zhao-Kun、Li Chun-Ran、Tian Nong、Yan Hao-Chen、Luo Jian-Yi、Xiao Ting-Hui
  • Journal Title: Optics Express Volume: 31 Pages: 6917～6917
  • DOI: 10.1364/OE.481253
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Highly Scalable, Wearable Surface‐Enhanced Raman Spectroscopy (2022)
  • Author(s): Liu Limei、Martinez Pancorbo Pablo、Xiao Ting‐Hui、Noguchi Saya、Marumi Machiko、Segawa Hiroki、Karhadkar Siddhant、Gala de Pablo Julia、Hiramatsu Kotaro、Kitahama Yasutaka、Itoh Tamitake、Qu Junle、Takei Kuniharu、Goda Keisuke
  • Journal Title: Advanced Optical Materials Volume: 10 Pages: 2200054～2200054
  • DOI: 10.1002/adom.202200054
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] On-chip chiral-field-enhanced Raman optical activity for biosensing (2022)
  • Author(s): Ting-Hui Xiao
  • Organizer: CLEO-PR
  • Int'l Joint Research