2021 Fiscal Year Final Research Report
Investigation of control mechanism of bone strength via copper as biotrace metal elements based on material engineering approach
Project/Area Number |
20K15048
|
Research Category |
Grant-in-Aid for Early-Career Scientists
|
Allocation Type | Multi-year Fund |
Review Section |
Basic Section 26040:Structural materials and functional materials-related
|
Research Institution | Osaka University |
Principal Investigator |
Ozasa Ryosuke 大阪大学, 工学研究科, 助教 (80845347)
|
Project Period (FY) |
2020-04-01 – 2022-03-31
|
Keywords | 生体必須金属元素 / 銅 / 骨組織 / 骨微細構造 / アパタイト配向性 / 骨強度 / 骨質 / 結晶集合組織 |
Outline of Final Research Achievements |
Bone tissue, which is a structural material, has a specific bone microstructure derived from ordered collagen fibers and the related apatite crystallites. Although the bone microstructure is widely recognized to regulate bone mechanical functions, formation mechanism of the structure in vivo remains unknown. The present study revealed the effects of copper as a biotrace metal element on bone material properties and suggested the possibility that copper contributes to control bone strength via regulation of the bone microstructure.
|
Free Research Field |
生体材料学
|
Academic Significance and Societal Importance of the Research Achievements |
本研究成果は、骨強度決定を担う骨微細構造の制御因子として、銅の関与を初めて示唆するものであり、骨健全化における生体必須元素の重要性を材料工学の観点より明らかにした。得られた知見は、骨組織の構造材料としての機能発現機序の一端を明らかにするものであり、骨脆弱性を呈する骨疾患に対する治療法や再生法の提案につながる可能性をもつ。
|