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2021 Fiscal Year Final Research Report

Development of array silicon chips for construction of highly efficient drug screening systems

Research Project

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Project/Area Number 20K15148
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 28050:Nano/micro-systems-related
Research InstitutionTohoku University

Principal Investigator

Tadaki Daisuke  東北大学, 電気通信研究所, 助教 (30794226)

Project Period (FY) 2020-04-01 – 2022-03-31
Keywords微細加工プロセス / シリコンチップ / マイクロアレイ / 脂質二分子膜 / 人工膜再構成系 / hERGチャネル / 無細胞タンパク質合成系 / 薬物スクリーニング
Outline of Final Research Achievements

In this study, to overcome a measurement throughput problem of conventional drug screening systems, we attempted to construct a highly efficient drug screening array system based on an artificial cell membrane reconstitution method. First, we successfully developed a multiple (16-) well microarray system consisting of multiple (16) independently mounted silicon (Si) chips with a single microaperture. By using a dry process with reactive ion etching (RIE), we also developed a method to fabricate array Si chips with multiple (16-) microapertures having a uniform edge structure. Although the development of an array system based on these chips was not completed due to new challenges, many important fundamental technologies were established for the construction of a highly efficient drug screening system.

Free Research Field

ナノマイクロシステム関連

Academic Significance and Societal Importance of the Research Achievements

本研究の成果である複数ウェル型マイクロアレイシステムの開発、及び複数微小孔搭載型アレイチップの作製法の確立は、いずれも人工膜再構成法に基づくイオンチャネル機能評価系における測定スループットを飛躍的に向上させるものであり、今後のイオンチャネル開閉機構解明のための研究を促進させる重要な成果である。また、応用開発の面では、測定スループットの向上により、創薬スクリーニング系における候補薬物の選定効率が上昇することで、新薬開発の加速化につながる画期的な成果だと言える。

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Published: 2023-01-30  

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