2021 Fiscal Year Research-status Report
Repurposing the novel DATB catalyst for the direct catalytic cross-coupling of carboxylic acids
| Project/Area Number |
20K15292
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| Research Institution | Microbial Chemistry Research Foundation |
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Principal Investigator |
OPIE Christopher 公益財団法人微生物化学研究会, 微生物化学研究所, 研究員 (90858531)
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | DATB / catalyst / boron / amide bond |
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| Outline of Annual Research Achievements |
The research direction has shifted twice from the original plan. When it was found that the "DATB catalyst" was not sufficiently powerful to activate carboxylic acids for incorporation into transition metal catalytic pathways, new catalyst designs were considered. The synthesis of these new compounds was found to be very challenging. Despite considerable effort, only one new interesting compound containing the DATB heterocycle was able to be synthesized, and it was found to have poor catalytic properties.
It was then hypothesized that molecules containing a N(BOH)2 moiety, which is related to DATB, would be able to activate carboxylic acids in a similar manner. This functional group is not known in the literature, and thus far 2 molecules containing it have been achieved.
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| Current Status of Research Progress |
Current Status of Research Progress
4: Progress in research has been delayed.
Reason
The research direction has shifted twice from the original plan after not being able to succeed in achieving the desired results. The current direction involves the synthesis of some unique compounds and heterocycles, however further time and effort is still required.
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| Strategy for Future Research Activity |
The current focus is on the isolation of the so-called N(BOH)2 moiety, which is expected to be able to activate carboxylic acids in a similar fashion to DATB. As has been the case with all compounds in this field, the synthesis has thus far proved to be quite challenging. Even with the successful synthesis of two separate N(BOH)2 containing compounds, stability issues have prevented their use as competent catalysts. Further modifications which would overcome these issues have been deliberated, and the synthesis incorporating these changes is ongoing.
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| Causes of Carryover |
Due to the ongoing situation with COVID-19, the funds that were set aside for conference travel have still not been able to be utilized. One conference was attended (PSJ 142, Nagoya, online - oral presentation).
Given the change in direction of the project, funds for article costs, predominately reactants and reagents, are still required.
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Research Products
(1 results)
