Development of Novel Chiral Porous Materials with Helicene Substructures

2021 Fiscal Year Final Research Report

• Project/Area Number: 20K15333
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 35010:Polymer chemistry-related
• Research Institution: Kyoto University
• Principal Investigator: Fujikawa Takao 京都大学, 高等研究院, 特定研究員 (70839688)
• Project Period (FY): 2020-04-01 – 2022-03-31
• Keywords: 多孔性材料 / 不斉空間 / 分子認識

Outline of Final Research Achievements

We have developed porous materials embedded with dynamic asymmetric structures and worked on the construction of a molecular recognition system based on a new mechanism through the analysis of the molecular adsorption process. The active sites of biomolecules, such as enzyme proteins, are omnidirectional and fluctuating chiral spaces, and thus have high molecular recognition ability and functionality. By bottom-up design starting from the synthesis of chiral organic ligands, we have reproduced a dynamic and asymmetric space inside metal-organic frameworks (MOFs) reminiscent of biomolecules and discovered an asymmetric adsorption/desorption process unprecedented for gas molecule adsorption materials.

Free Research Field

錯体化学、有機化学

Academic Significance and Societal Importance of the Research Achievements

物質の変換・分離・精製プロセスは現代の物質社会を根幹から支えるインフラ技術である。特にエネルギー資源、ポリマー材料、医薬品源薬などといった分子性資源の加工には膨大なエネルギーが必要とされている。高い精度でこれらの分子性資源を吸着できる分子認識場を開発できれば、高効率で低コストな物質変換プロセスの構築が可能となる。本研究は、新たな分子メカニズムに基づく分子認識場の構築手法を提案するものであり、次世代の物質分離技術や物質変換技術の開発に資するものである。