A Controlled Synthesis of Platinum-Zinc Colloid Using Polymer Micellar Core as a Reaction Field toward the Optimized Antioxidant Effect

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K15346
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 35020:Polymer materials-related
• Research Institution: Tokyo University of Science
• Principal Investigator: Shigehito Osawa 東京理科大学, 理学部第一部応用化学科, 助教 (30780663)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 白金錯体 / 亜鉛錯体 / ジピコリルアミン / DNA / ナノ粒子

Outline of Final Research Achievements

Random copolymers containing zinc and platinum complexes were synthesized by reversible addition-fragmentation chain transfer polymerization of acrylate monomers having zinc- and platinum-complexed structures. We obtained two copolymers termed as Zn2/Pt1 and Zn1/Pt1; degree of polymerization of the zinc/platinum complexes monomers are 24/12 and 16/15 in Zn2/Pt1 and Zn1/Pt1, respectively. When Zn2/Pt1 and Zn1/Pt1 were mixed with pDNA, nanoparticles were obtained with 31 nm and 74 nm in average hydrodynamic diameter. Elemental analysis of the obtained particles during scanning transmission electron microscopy observation revealed that the particles contained phosphorus derived from pDNA and the zinc and platinum derived from the copolymer, verifying that nanoparticles were formed from the copolymers using DNA as the template. The obtained nanoparticles showed no toxicity to the cultured normal human dermal fibroblasts and accelerated the decomposition of hydrogen peroxide.

Free Research Field

高分子化学

Academic Significance and Societal Importance of the Research Achievements

白金や白金錯体をナノ粒子化することによるクラスター効果で触媒活性が向上することはよく報告されているが、本技術では、ナノ粒子中で亜鉛がスペーサーとして白金の間に存在することで、さらに白金の有効な触媒面が大きくし、白金グラムあたりの触媒活性を高めることが期待される。白金、白金錯体は様々な場面で貴重な触媒成分となるが、白金自体は貴金属である。白金の使用量削減につながると期待される本技術は、種々の場面で持続可能な開発目標の達成にも貢献すると考えられる。