2022 Fiscal Year Annual Research Report
The potential beneficial effects of inactivated Bifidobacterium Longum on the alleviation of muscle atrophy and physical fatigue in aged hospitalized and athletes using in vitro and in vivo models.
| Project/Area Number |
20K15466
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| Research Institution | University of Tsukuba |
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Principal Investigator |
BEN・OTHMAN MAHMOUD 筑波大学, 健幸イノベーション開発研究センター, 研究員 (40868337)
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | Muscle atrophy / Treadmill / Power strength |
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| Outline of Annual Research Achievements |
In order to evaluate the effect of Bifidobacterium longum extract on anti-fatigue and muscles atrophy in mice, we perform some exercises on mice. We created a muscles atrophy by cast immobilization of mouse's hindlimb for 10 days.
The results showed a significant increase of running distance of BL-treated mice compared with non-treated mice. Moreover, the power strength of muscles was significantly increased in dose dependent manner in treated groups compared with non-treated group. Finally, BL at 50mg/kg significantly increased the muscles weight compared with non-treated mice.
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